MIT9_14S09_prob13

MIT9_14S09_prob13 - 9.14, MIT, Spring 2009 Class #13-14...

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9.14, MIT, Spring 2009 Class #13-14 Questions based on lectures and Schneider text: 1. Describe three roles of neurotrophins in the brain. 2. Describe or name two effects of hormones on brain development. 3. Contrast two major possible purposes in naturally occurring neuronal death. 4. Give an example of innervation-dependent neuronal death/survival. Some of the following questions may require some web searching, or questions for the professor in the classroom: 5. Contrast apoptosis and necrosis. 6. What are trk receptors? (What binds to them, and what is the result?) 7. How is the intracellular protein bcl-2 involved in regulating the above processes? 8. Describe the effects of overexpressing bcl-2 in vivo in mice by generating mice in which a bcl-2 transgene is placed under the control of an exogenous promoter (i.e., a promoter which comes from a different gene) and which, for example, triggers the expression of the bcl-2 transgene specifically in neurons.
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This note was uploaded on 11/11/2011 for the course BIO 9.07 taught by Professor Ruthrosenholtz during the Spring '04 term at MIT.

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MIT9_14S09_prob13 - 9.14, MIT, Spring 2009 Class #13-14...

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