pd_memory_intro

pd_memory_intro - Parkinson’s disease and Memory Christie...

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Unformatted text preview: Parkinson’s disease and Memory Christie Chung 8/2/06 PD and Memory ¡ PD without dementia impairs declarative memory processes ¡ Recall ¡ Recognition (Recollection and Familiarity) ¡ Prospective memory ¡ Metamemory ¡ Moderators: task difficulty, disease severity, depression Recall in nondemented PD ¡ PD impairs both verbal and nonverbal recall (Bowen et al., 1976; Halgin, 1977; Cooper et al., 1993) ¡ Especially when information is not semantically organized (Tweedy et al., 1982; Villardita et al., 1982; Weingartner et al., 1984) Recall deficit in PD ¡ Recall deficit is present in early-onset PD and is not worse in the late-onset form of the disease ¡ Deficit also observed in early, untreated PD ¡ Dopaminergic and cholinergic neuronal systems influence acquisition and retrieval of information in PD, but not storage of information (challenged view!) Recognition in PD Mixed results: ¡ Some found no deficit in recognition (e.g., Flowers et al.,1984; Taylor et al., 1986) ¡ Others found decline (e.g., Tweedy et al., 1982; Hay et al., 2002; Davidson et al., 2006) Why mixed results? ¡ Floor or ceiling effects? ¡ Statistical power (Whittington et al., 2000) ¡ 48 studies, mean power to detect small effects was 20% ( ⇑ Type II error) ¢ Meta-analysis showed small deficits in recognition in nondemented PD patients Dual-process models ¡ Recognition based on two processes: ¡ 1) Recollection -- vivid, clear memory of an item and context around it ¡ 2) Familiarity -- intuitive feeling of encountering the item without awareness of context Brain regions implicated ¡ Recollection -- both frontal and hippocampus proper ¡ Familiarity -- parahippocampal and perirhinal cortex ¡ PD: Mesocortical pathway deficits, dysfunction of connections between the basal ganglia and temporal lobes, and reduced MTL volume leads to prediction of recollection and familiarity decline Recollection and Familiarity in PD ¡ Hay et al. (2002) used Process Dissociation Task (PDP) to estimate recollection and familiarity in PD and amnesia (MTL lesion) ¡ Moderate PD patients showed impairment in recollection (frontal) and familairity (striatal dysfunction) compared to controls and mild PD patients ¡ Amnesics showed impairment in recollection and intact familairity Prospective Memory in PD ¡ Remembering to execute an action ¡ Time-based / event-based tasks (Einstein & McDaniel, 1990) ¡ Very few studies despite prevalence in everyday life ¡ Likely involves frontal and executive functions (planning) which are impaired in PD Previous findings...
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This note was uploaded on 11/11/2011 for the course BIO 9.07 taught by Professor Ruthrosenholtz during the Spring '04 term at MIT.

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pd_memory_intro - Parkinson’s disease and Memory Christie...

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