Lecture 13. Cell signaling

Lecture 13. Cell signaling - cell signaling: how cells...

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EXTRACELLULAR FLUID Receptor Signal molecule Relay molecules in a signal transduction pathway Plasma membrane CYTOPLASM Activation of cellular response cell signaling: how cells detect and respond to chemical information such as pheromones or hormones Reception 1 Transduction 2 Response 3 Every chemical signaling system consists of three parts 1. Reception-detection of the signal by a receptor protein 2. Transduction-conversion of the information into cellular language 3. Response-the cell’s reaction
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The β adrenergic receptor is a member of a class of plasma membrane proteins known as G protein- coupled receptors that work with the help of a G protein The G protein acts as an on/off switch: If GDP is bound to the G protein, the G protein is inactive. However if the GDP is removed and replaced by GTP the G protein is active. Epinephrine (the signal) is detected by an integral membrane protein called the beta adrenergic receptor
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We will examine one system in detail—epinephrine, the “fight or flight” hormone This signal is detected by the β- adrenergic receptor , an integral membrane protein that spans the membrane seven times. The extracelluar domain binds to epinephrine and causes a shape change in the transmembrane domain that modifies the interaction of the cytoplasmic domain with a G protein
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The G protein acts as a “molecular switch”. With GTP bound the switch is
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This note was uploaded on 11/14/2011 for the course BSC 2010 taught by Professor Pf during the Spring '08 term at FSU.

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Lecture 13. Cell signaling - cell signaling: how cells...

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