Clostridial food poisoning. Clostridial food poisoning is due to Clostridium perfringens , a sporeforming, anaerobic rod. This organism produces its toxin in meat, and consumption of contaminated meat leads to mild gastroenteritis, with diarrhea. The infection is self-limiting and rarely requires antibiotic therapy. Clostridium botulinum also is transmitted in contaminated food. Its toxin affects the nervous system. Leptospirosis. Leptospirosis is a disease of animals (such as dogs) as well as humans, where it causes damage to the liver and kidney. The etiologic agent is Leptospira interrogans , a spirochete. Humans usually become infected by contact with urine of the animals as the spirochete enters abrasions in the skin. Patients suffer muscle aches, fever, and infection of the liver. Kidney failure may also occur. Penicillin antibiotics are used for therapy.
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