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Immunodeficiency Diseases

Immunodeficiency Diseases - Such a condition may result...

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Immunodeficiency Diseases Disorders of the immune system may also be due to deficiencies of the system. These deficiencies  may be  congenital  or  iatrogenic  (induced by immunosuppressive drugs), or they may result from  malignancies occurring in the lymphatic system.  Abnormalities of the B-lymphocytes result in an immunodeficiency accompanied by abnormal  production of antibodies. These abnormalities may result from infections such as diseases of the  liver, from immune complex disorders such as systemic lupus erythematosus, or from malignancies.  Multiple myeloma is a malignant disease of plasma cells in which certain clones of B-lymphocytes  produce an overabundance of antibodies. The antibodies are excreted into the urine, where they are  known as Bence Jones proteins. Decreased ability of the B-lymphocytes to produce antibodies is called 
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Unformatted text preview: hypogammaglobulinemia. Such a condition may result from a genetic defect or the failure of the body to produce B-lymphocytes. Bone marrow disorders may also be a cause. Abnormalities of the T-lymphocytes result in reduced capacity for cell-mediated immunity. This condition, called DiGeorge's syndrome , often develops from malformation or absence of the thymus gland. An individual with this syndrome is highly susceptible to infection by fungi, protozoa, and viruses. When both B-lymphocytes and T-lymphocytes are deficient, the condition is called severe combined immunodeficiency. Recent procedures employing transplantation of bone marrow tissue have attempted to relieve this condition....
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  • Fall '08
  • Farr
  • Systemic lupus erythematosus, Immunodeficiency, Primary immunodeficiency, bone marrow tissue, immune complex disorders, Bone marrow disorders

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