Lecture 11_07 - It looks like this when it is at the plasma...

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Main Ideas Targeting proteins to the right cellular location. What are mutations and how are they caused? What effect do mutations have on protein function? The Genetic Code handout– pick one up in front.
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Fig. 17-24 RNA polymerase DNA Polyribosome mRNA 0.25 µm Direction of transcription DNA RNA polymerase Polyribosome Polypeptide (amino end) Ribosome mRNA (5 end) Transcription and translation occur simultaneously in prokaryotes.
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Translation occurs in the cytoplasm or at the ER membrane in eukaryotes.
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Transmembrane and secreted proteins are made at the rough ER. A short peptide sequence at the N-terminus of the protein is a signal for it to be synthesized at the ER.
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Protein A is a transmembrane protein that spans the membrane one time. It looks like this when it is at the plasma membrane… Where is the N-terminus of this protein? A. Outside the cell B. Inside the cell C. In the interior of the membrane D. I need more information to answer E. I don’t know
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Protein A is a transmembrane protein that spans the membrane one time.
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Unformatted text preview: It looks like this when it is at the plasma membrane The N-terminal amino acid of this protein is A. Glycine B. Methionine C. Aspartic Acid D. I need more information to answer. E. I dont know. A polypeptide must be processed and folded to make a functional protein. Mutation A heritable change in DNA What causes mutations? Spontaneous mutation Errors in DNA synthesis Errors in meiosis Chromosome breakage and repair Induced mutation Chemicals Radiation Mutations are occurring all the time. What is the affect of a mutation in a somatic cell? A germ-line cell? In what ways can DNA be changed? Point mutations Single nucleotide change Chromosomal mutations Deletion Insertion Inversion Translocation A mutation in DNA can affect gene regulation Change in how much protein made. A mutation in DNA can affect protein function. The affect of a mutation depends on the genetic code....
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This note was uploaded on 11/10/2011 for the course HDF 304 taught by Professor Gray during the Spring '08 term at University of Texas at Austin.

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Lecture 11_07 - It looks like this when it is at the plasma...

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