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Unformatted text preview: ASPIRIN
Name Section Date Partner's Name
1. Mass of salicylic acid 2. Milliliters of acetic anhydride 3. Odor of flask after the addition of water 4. Appearance of crude product 5. Mass of dried recrystallized product 6. Appearance of recrystallized product 7. Melting point of salicylic acid 8. Melting point of pure aspirin (provided by instructor) 9. Melting point range of dried product 10. Melting point range of mixture of salicylic acid plus product 11. Melting point range of mixture of known aspirin plus product Calculations Show your work below or on a separate sheet of paper.
1. Moles of salicylic acid 2. Moles of acetic anhydride 3. Limiting reagent 4. Theoretical yield, grams 5. Percent yield 6. Retention Factor of salicylic acid 7. Retention Factor of known sample of aspirin 8. Retention Factor of product
1 Report the data used to calculate your retention factors: 9. List some key absorption wave numbers of salicylic acid and the product and the
associated functional group and vibration. Salicylic Acid
Wavenumber Functional Group Vibration Product
Wavenumber Functional Group Vibration 10. Attach all chromatograms and IR spectra. Make sure that each of these is properly
labeled according to your instructor’s specifications. 11. Submit your product to your instructor in a vial. Label the vial with the name of the
product, your name and your partner's name. 2 ASPIRIN
Name Section Date 1. Draw the structural formulas for the reactants used in the synthesis of aspirin and indicate
all the bonds which have been broken in the reactants and all the bonds formed in the
products during the reaction. 2. What is the melting point of your product? Is your melting point range narrow (<2°) or it
is broad (>2°C)? What does the range tell you about your product?
3. Can you decide from just the melting point of your product if it is aspirin? Explain your
4. What is your melting point of the mixture of your product and pure aspirin? Is the range
narrow or broad? What does this tell you about the identity of your product?
3 5. What is the melting point of the mixture of your product with salicylic acid? Is it narrow
or broad? What can you conclude about the identity of your product from this data?
6. Compare the IR spectrum of your product to the spectrum of the salicylic acid and to the
spectrum of the product provided by your instructor.
7. Based on all of the data obtained in this experiment, did you make pure aspirin? Why or
why not? (Support your claim using melting point, TLC and IR data.)
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This note was uploaded on 11/13/2011 for the course ECON 122 taught by Professor Lollol during the Spring '11 term at Carlos Albizu.
- Spring '11