ECE_3820_lecture_14_2011

ECE_3820_lecture_14_2011 - Today (10/18), lecture #14 1)...

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Today (10/18), lecture #14 1) Answers for HW#4 are on the Blackboard site. 2) Hodgkin-Huxley equations for a nerve action potential. 3) Begin principles of hemodynamics. Thursday (10/20), lecture #15 1) Quiz #6. (Reading #6 and HW set #4). Bring your calculator. 2) Continue principles of hemodynamics.
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Voltage clamp plots
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From lecture #11: 1) Hodgkin and Huxley represented the nerve cell membrane as an analogue circuit. 2) They performed voltage clamp experiments to measure ionic currents flowing across the cell membrane. “Early” and “late” membrane currents were measured. 1) Early inward current (lasts 1-2msec) 2) Latent outward current Inward current bulge Outward current bulge Latent outward current No early current = A big hint that flow of Na+ ions constitutes the early current. ENa+ is also a good approximation of the Na+ current reversal potential . Because bulge is inward for Vclamp < ENa and bulge is outward for Vclamp > ENa. 117-60=57mV E K -84mV E Na 52mV Reversal potential occurs when the early inward current equals zero.
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Current vs. voltage plots
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Current-voltage curves describe membrane operating conditions. Plot peak currents versus clamped transmembrane potential voltage (Vm). I
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ECE_3820_lecture_14_2011 - Today (10/18), lecture #14 1)...

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