Unformatted text preview: from skin. Release rate tended to increase when FD-4 was administered dividedly by multiple injections. Release profiles of FD-4 were expressed by Fick’s law of diffusion, which was covered in our class. Furthermore, a combination of the formulation strategy and hollow microneedle-assisted delivery was useful for controlling the drug release rate from skin. Release profiles from drugloaded skin were also compared by changing the molecular weights of model compounds. The larger molecular size of compounds caused a lower release rate from skin. These results suggest the utilization of hollow microneedle to enhance transdermal delivery of large molecular compounds and provide useful information for designing an effective hollow microneedle system....
View Full Document
- Spring '08
- Molecule, release rate, hollow microneedle, hollow microneedle array-patch, effective hollow microneedle