transportII research

transportII research - from skin Release rate tended to...

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Marcin Rosol Drug Delivery Authors: Nanthida Wonglertnirant, Hiroaki Todo, Praneet Opanasopit, Tanasait Ngawhirunpat, and Kenji Sugibayashi Title: Macromolecular Delivery into Skin Using a Hollow Microneedle Journal: Biological and Pharmaceutical Bulletin, Vol. 33, 2010, pp. 1988-1993 Abstract: This study obtained information to develop a hollow microneedle array-patch system. The hollow microneedle was investigated for enhancing the transdermal delivery of hydrophilic large molecular compounds and the effect of variable parameters on drug release behavior was determined from skin. Fluorescein isothiocyanate (FITC)-dextrans (4.3 kDa), FD-4, was used as the main model compound, and it was loaded into the skin of hairless rats by a hollow microneedle. The higher the volume of FD-4 solution injected, the faster the FD-4 release rate
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Unformatted text preview: from skin. Release rate tended to increase when FD-4 was administered dividedly by multiple injections. Release profiles of FD-4 were expressed by Fick’s law of diffusion, which was covered in our class. Furthermore, a combination of the formulation strategy and hollow microneedle-assisted delivery was useful for controlling the drug release rate from skin. Release profiles from drugloaded skin were also compared by changing the molecular weights of model compounds. The larger molecular size of compounds caused a lower release rate from skin. These results suggest the utilization of hollow microneedle to enhance transdermal delivery of large molecular compounds and provide useful information for designing an effective hollow microneedle system....
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