AP_Bio_-_dna_struc_and_replic

AP_Bio_-_dna_struc_and_replic - DNA Structure &...

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AP Bio Ch 12
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Discovering the chemical nature of DNA: Griffith
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Discovering the chemical nature of DNA: Hershey-Chase
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Okay, if DNA is the hereditary material, what does it look like?
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How could DNA replication occur? 3 ideas: Conservative Semiconservative Dispersive Watson & Crick proposed based on structure Meselson & Stahl tested this Online tutorial
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The Replication Origin Replication requires a starting point: the Replication Origin Prokaryotes have one, eukaryotes have 100s or 1000s Specific sequences E. coli has 246 base pairs in its RO
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Starting Replication Replication starts with Helicases Break H-bonds & open up “bubbles” in the dsDNA After Helicase “unzips” the DNA, other proteins play a role: DNA single strand binding proteins DNA gyrase (topoisomerase II)
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DNA Polymerase Function Limitation – can only add new nucleotides to the 3’ end of an existing nucleotide strand Solution: Primase
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AP_Bio_-_dna_struc_and_replic - DNA Structure &...

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