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Evidence for Evolutio2 - Evidence for Evolution Exons...

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Evidence for Evolution Exons and "The Curly Shuffle" I've mentioned the term exon shuffling in several of my posts, so I might as well get around to explaining what the hell I'm talking about. This is especially true since there is a paper in this weeks Science about the "Exon Universe" that will be the second part of this article. In this introduction to the paper, I'll explain a little about gene structure and what exon shuffling is. (Keep in mind that DNA codes for RNA which codes for protein) The bacteria E. Coli was used in most of the very first molecular genetics experiments. When the first genes were sequenced from it, it was found that all the information for the protein lay in one continuous stretch (an open reading frame (ORF)). It came as a bit of a surprise when the first eukaryotic genes were sequenced and this was not the case. It seemed typical eukaryotic genes contained several open reading frames of DNA interrupted by sequences of DNA that did not code for anything. The coding regions were dubbed exons and the intervening sequences were
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