Evidence for Evolutio7

Evidence for Evolutio7 - Evidence for Evolution Mullers...

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Evidence for Evolution Mullers ratchet in an RNA virus In this paper Lin Chao propagated 20 lineages of the RNA virus, phi 6. This virus was chosen for two reasons. One, it is asexual. (Actually, it has three distinct regions that can be recombined, but recombination can not occur within these regions.) And two, it has a mutation rate several orders of magnitude higher than similar DNA viruses. (In addition, DNA viruses reproduce sexually.) All 20 lineages derived from a single parent virus. In each lineage he subjected the virus to 40 growth cycles. Each cycle consisted of picking a single virus and growing up a population of 8*10^9 viruses from it. So, the virus was subjected to 40 bottlenecks to intensify drift. If the single virus chosen contained a mutation, the mutation could not be rectified. The ratchet had clicked a notch. (Intensifying drift corrected for the fact that a small amount of recombination is possible in this virus as I mentioned before.)
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This note was uploaded on 11/14/2011 for the course BIO BSC1010 taught by Professor Gwenhauner during the Fall '10 term at Broward College.

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Evidence for Evolutio7 - Evidence for Evolution Mullers...

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