Molecular suboptimality

Molecular suboptimality - Molecular suboptimality The...

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Molecular suboptimality The principle of imperfect design should apply to biomolecular organization as well. Confirmation: With the recent sequencing of the human genome, we have found that less than 2% of the DNA in the human genome is used for making proteins (International Human Genome Sequencing Consortium 2001, p. 900). A full 45% of our genome is composed of transposons, which serve no known function for the individual (except to cause a significant fraction of genetic illnesses and cancers) ( Deininger and Batzer 1999 ; Ostertag and Kazazian 2001 ). One retrotransposon, LINE1, constitutes a full 17% of the human genome ( Ostertag and Kazazian 2001 ; Smit 1996 , IHGSC 2001 , p. 879-882). All specific individual Alu transposons tested so far have been shown to be nonfunctional ( Deininger and Batzer 1999 ). Thus, even if these genetic elements in fact provide a bona fide function as a whole, they would remain some of the most inefficient genes known in all of biology due to thier excessive number and their known propensity to cause
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This note was uploaded on 11/14/2011 for the course BIO BSC1010 taught by Professor Gwenhauner during the Fall '10 term at Broward College.

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Molecular suboptimality - Molecular suboptimality The...

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