Cognitive Control Processes and Working Memory in Parkinson

Cognitive Control Processes and Working Memory in Parkinson...

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Cognitive Control Processes  and Working Memory in  Parkinson's Disease  Early stage idiopathic Parkinson's disease (PD) is characterized by the  three classic motor symptoms: rigidity, tremor, and bradykinesia. The  core pathological hallmark of PD is the progressive loss of dopamine  (DA) neurons in the ventrolateral tier of the substantia nigra pars  compacta which primarily projects to the dorsal striatum (Fearnley and  Lees, 1991; Kish, Shannak, and Hornykiewicz, 1988). The severely DA  depleted dorsal striatum sends efferents, via the nigrostriatal pathway, to  the supplementary motor area and distinct areas of the PFC, namely the  dorsolateral PFC and ventrolateral PFC (Middleton and Strick, 2000a;  Middleton and Strick, 2000b). Less severely affected are direct 
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Unformatted text preview: dopaminergic projections from the ventral tegmental area (VTA) to the PFC via the mesocortical pathway (Uhl, Hedreen, and Price, 1985). Due to the strong reciprocal connections between the striatum and specific areas of the frontal cortex, PD pathology results in a host of executive deficits, such as planning, attentional set-shifting, and working memory. These cognitive deficits are similar, but not identical, to ones observed with frontal lobe damage (Owen et al., 1992). This set of slides describes the executive deficits after frontal lobe lesions, and then compares them to the executive deficits seen in PD....
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This note was uploaded on 11/14/2011 for the course PSY PSY2012 taught by Professor Scheff during the Fall '09 term at Broward College.

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