Unformatted text preview: relation is seen in cross-sectional studies (Tanner, Ottman et al., 1999; Wirdefeldt, Gatz et al., 2004). Over the past decade, several causative genes have been identified in kindreds demonstrating a Mendelian incidence of disease. Parametric, genome-wide association studies have also revealed multiple susceptibility loci (Pankratz, Nichols et al., 2002; Scott, Nance, et al., 2001). Besides a handful of exceptions, however, these genetic factors exhibit a greatly reduced penetrance and unique molecular pathologies that confound attempts to adequately explain the causes of sporadic PD. While it now appears that the disease has a significant genetic component, the causative factors of sporadic PD may represent a more heterogeneous balance of genetic predisposition and environmental exposure....
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This note was uploaded on 11/14/2011 for the course PSY PSY2012 taught by Professor Scheff during the Fall '09 term at Broward College.
- Fall '09