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Neuropathology and Structural Neuroimaging in Parkinson

Neuropathology and Structural Neuroimaging in Parkinson -...

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Neuropathology and Structural  Neuroimaging in Parkinson's  Disease  The major neuropathologic feature of idiopathic Parkinson's disease  (PD) is a selective loss of dopaminergic neurons in the substantia  nigra pars compacta (SNpc), accompanied by Lewy bodies and  neurites, although neuropathological studies suggest abnormalities  exist in other brain regions as well. Many of the cognitive deficits in PD  may stem from abnormalities in nonmotor circuits of the basal ganglia  (particularly the fronto-striatal loop, including the anterior caudate and  dorsolateral prefrontal cortex), which may be affected by dopamine 
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Unformatted text preview: loss in the same way as the motor circuits. This workshop was designed to provide a broad overview of the most current literature regarding neuropathological and neuroimaging findings in idiopathic PD. The papers presented and discussed at this workshop focused on abnormalities in the striatum, brainstem, thalamus, hippocampus, amygdala, the cholinergic and serotoneric brainstem nuclei, and cerebral cortex. Current limitations and recent advances in the application of structural neuroimaging methods to studying PD were also discussed....
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  • Fall '09
  • SCHEFF
  • Psychology, Dorsolateral prefrontal cortex, idiopathic Parkinson, structural neuroimaging methods, serotoneric brainstem nuclei, major neuropathologic feature, cortex. Current limitations

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