16_Anterograde - “Bottom-up” deficits(Hodges Salmon&...

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Anterograde Amnesia &  Dementia
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Cortical & Frontal Anterograde  Amnesia Cortical - Semantic dementia Alzheimer’s Frontal – Poor recall Basal Ganglia Huntington’s
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Alzheimer’s Disease (AD) 1 Result of plaques  throughout cortex;  early detection now  possible; anti- inflammatories (e.  g., aspirin,  ibuprophren) reduce  symptoms
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Dementia Because there is damage beyond the  hippocampus, skills that are not  impaired in medial temporal amnesia  are impaired in dementia.
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Alzheimer’s Disease 2 As with other amnesias, procedural  memory remains intact. However, generalized damage affects  semantic memory, so priming and  implicit memory deficits are seen. Faster forgetting than others, though. Verbal fluency problems.
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Unformatted text preview: “Bottom-up” deficits. (Hodges, Salmon, & Butters, 1992). Huntington’s Disease (HD) Caudate nuclei of basal ganglia die over time Patient loses ability to make voluntary responses. Inability to make voluntary response reduces imagery and verbal rehearsal strategies. Results in poorer recall than recognition. Frontal Anterograde Amnesia The frontal cortex directs action Bilateral damage to the frontal cortex can impair voluntary actions that are mnemonics, hence impairing learning Narrative processes the ultimately make recall possible severely disrupted. Hence recall is ultimately disproportionately impaired...
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