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class+19+lecture+_olfaction3_ - The Neurobiology of Smell:...

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Unformatted text preview: The Neurobiology of Smell: From Synapses to Perception (Part 3) Current Research in Dr. McGanns Laboratory n Experience-dependent plasticity n Effects of exposure to environmental toxicants n Top-down shaping of odor representations Experience-Dependent Plasticity (current research in Professor McGanns laboratory) The circuitry of the olfactory system changes depending on its environment and experience. What sensory experiences might cause these changes? q Olfactory sensory deprivation q Exposure (single odors or mixtures) q Associative Learning (fear/reward, mixture discrimination) What is the corresponding change in odor representation & perception? Experience-dependent plasticity in the olfactory system Occluded Control Effects of Acute Intranasal Cadmium Exposure n Intranasal exposure can permit neurotoxicants to bypass the blood-brain barrier. n Common workplace exposures to aerosolized toxicants. q Heavy metals (cadmium, manganese, lead, etc.) q Solvents (paint, etc.) q Volatile organic compounds (vehicle exhaust, etc.) q Diesel particulate matter Cadmium exposure and human health n Forms of inhalation exposure q Smoking a pack of cigarettes leads to absorption of 1-3 g Cd/day....
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class+19+lecture+_olfaction3_ - The Neurobiology of Smell:...

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