Lecture 30 SRR F-2011

Lecture 30 SRR F-2011 - Biology 313, Lecture 30 Nov 11,...

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Unformatted text preview: Biology 313, Lecture 30 Nov 11, 2011 Joan Miro (Catalan, Barcelona) Chapter 11 : Chromosome Structure Problems (through Ch. 11 ) Concept Checks (1-7) Worked Problems: 1 Comprehension and Application Questions at end of Chapter: 1-11; 24-27; 29; 31-32 Types of Transposons Transposon types differ in: 1. Their general structure 2. The way they move There are two classes of transposons: Class I: Retrotransposons (retroelements) Class II: DNA transposons Retrotransposons similar to retroviruses Retroviruses : RNA viruses that can integrate into host genome ( Chapter 8: 227-231 ) Retroviruses All retroviral RNA genomes have in common three genes; these three genes code for a precursor protein (inactive) that is clipped into 2 or more (functional) proteins gag codes for viral coat proteins pol codes for reverse transcriptase (RT) and integrase (inserts DNA into host genome) env code for envelope glycoproteins Retrovirus life cycle HIV ( Human Immunodeficiency Virus ): cause of AIDS (acquired immune deficiency syndrome) Two different HIV: HIV-1 (global) & HIV-2 (W. Africa) Transmitted via blood contact, sex contact Genome carries gag, pol, env genes: RT is error prone, so mistakes occur, making vaccine development hard HIV Patient dies because cant fight off infections or pathogens HIV attacks and replicates in helper T cells in blood important for immune function Loss of T- cells causes compromised immune function HIV HIV arose from recombination between two simian immunodeficiency viruses (SIV) SIV does not cause AIDS in chimps SIV was transferred several times to humans Mechanisms of transposition: retrotransposons (retroelements) Transposition occurs via an RNA...
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This note was uploaded on 11/17/2011 for the course BIOLOGY 313 taught by Professor Steverodermel during the Fall '11 term at Iowa State.

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Lecture 30 SRR F-2011 - Biology 313, Lecture 30 Nov 11,...

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