lect16 - Ch395G Fall 2009: Lecture 16 Enzymatic Catalysis...

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Unformatted text preview: Ch395G Fall 2009: Lecture 16 Enzymatic Catalysis And Control Enzyme Catalysis Lysozyme as an example look for how rate is enhanced and the methods used to determine mechanistic information. iochemical Data Biochemical Data Structural Data Phillips Mechanism Recent Developments Summary What chemical mechanisms were employed in Lysozyme? What methods provided the data to work out the current mechanism? Correction I had noted earlier that procaryotes do not carry out protein glycosylation and that this resulted in problems for making some effective eucaryotic recombinant proteins in bacterial hosts. Recently it was discovered the Campylobacter jejuni can do both N- and O- linked glycosylation. The systems for doing this glycosylation have now been transferred to E.coli . Control of Enzymatic Activity Rates of synthesis and degradation (Nobel Prize r the ubiquitination pathway) See Chapter 13 pages 465 - 470 for the ubiquitination pathway) Proenzyme (zymogen) conversion Presence of activators and inhibitors Covalent Modification Allosteric Control From the National Museum of Medicine...
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lect16 - Ch395G Fall 2009: Lecture 16 Enzymatic Catalysis...

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