lect18 - A stripped down Figure of Glycolysis Fates of...

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A stripped down Figure of Glycolysis
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Fates of pyruvate Other sugars (than glucose) Energetics of glycolysis Gluconeogenesis Regulation of glycolysis/gluconeogenesis
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Fates of Pyruvate
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Stage 2: x2 1 oxidation 2 substrate level phos. 11a. Anaerobic Glycolysis – Reduction of Pyr to Lactate: Lactate DH pyruvate + NADH + H+ lactate + NAD+ - Pyruvate is reduced to lactate to recover NAD+ needed for glycolysis - This is a reversible reaction – several isoenzyme forms of LDH 10 11
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Figure 17-24 Reaction mechanism of lactate dehydrogenase. Page 603
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Reduction of pyruvate to lactate: lactate dehydrogenase pyruvate + NADH + H+ lactate + NAD+ •reduced at expense of electrons originally donated by 3-phosphoglyceraldehyde, carried by NADH. Thus, no net oxidation occurs in glycolysis = fermentation; another organic serving as electron acceptor. •lactate, end-product under anaerobic conditions, diffuses thru cell membrane as waste into blood - salvaged by liver and rebuilt to form glucose ( gluconeogenesis ). This occurs in skeletal muscle during periods of strenuous exertion: Cells use O2 faster than can be supplied by circulatory system; cells begin to function anaerobically, reducing pyruvate to lactate rather than further oxidation. Causes soreness due to decreased pH. Lactate fermentation also important commercially since bacteria capable are responsible for production of cheeses, yogurts, and other foods obtained by fermentation of lactose of milk.
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Stage 2: x2 1 oxidation 2 substrate level phos. 11
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This note was uploaded on 11/16/2011 for the course CH 370 taught by Professor Hackert during the Spring '08 term at University of Texas.

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lect18 - A stripped down Figure of Glycolysis Fates of...

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