lect21 - Glycogen Metabolism We have dealt with glucose...

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Glycogen Metabolism We have dealt with glucose catabolism and resynthesis and also the use of other sugars. So far we have not discussed the use of glycogen, the storage form of glucose, nor its synthesis. Glycogen is stored primarily in the muscles, and the liver. Muscles need vast amounts of ATP for contraction, and glycolysis can generate ATP as much as 100 times faster than TCA – sperm also depend on glycolysis for motility. The liver’s glycogen depot is largely used to maintain blood glucose levels .
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G-1-P Glycogen (n) UDP -Glucose Glycogen (n-1) Glycogenolysis Glycogen Synthesis Glycogen (n-1) UTP PP 2P
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Figure 18-1a Structure of glycogen . ( a ) Molecular formula. Page 627
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Figure 18-3: The reaction mechanism of glycogen posphorylase . Page 630
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Figure 18-5/8 Reactions catalyzed by debranching / branching enzymes. Page 631 debranching branching
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Figure 18-4 The mechanism of action of phosphoglucomutase . Page 631
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Figure 18-6 Reaction catalyzed by UDP–glucose pyrophosphorylase. Page 633 Synthesis – Step 1
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Figure 18-7 Reaction catalyzed by glycogen synthase . Page 633 O Synthesis – Step 2 Non-reducing end New non-reducing end
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G-1-P Glycogen (n) UDP -Glucose Glycogen (n-1) Glycogenolysis Glycogen Synthesis Glycogen (n-1) UTP PP 2P
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Figure 18-9 The control of glycogen phosphorylase activity. Page 635
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X-Ray structure of rabbit muscle glycogen phosphorylase . ( a ) Ribbon diagram of a phosphorylase b subunit. Page 628
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This note was uploaded on 11/16/2011 for the course CH 370 taught by Professor Hackert during the Spring '08 term at University of Texas at Austin.

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lect21 - Glycogen Metabolism We have dealt with glucose...

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