Epidemiologyresearchpaper - Hailey Holman MBI 361 Research...

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Hailey Holman MBI 361 Research Paper Alcohol Consumption and the Risk of Colorectal Cancer It is the second leading cause of death in the United States and one of the most emotionally charged words in the English language: cancer. There are about 1.4 million cases diagnosed each year and these shocking rates continue to rise. (National Cancer Institute) With over 200 types of cancer, there are naturally a wide range of causes. It seems that we are constantly hearing of new studies showing a correlation between seemingly harmless products of everyday life and this nasty disease. From Diet Coke to hot dogs, there is always a new study placing additional fear into the already worried minds of Americans. There has been a recent interest in investigating the risk of cancer as a result of alcohol consumption. There are several suggestions as to why we may see this correlation. The first attributable factor is acetaldehyde. This is an oxidation product of alcohol that may be responsible for colorectal carcinogenesis. A second potential cause is due to the fact that alcohol is an antagonist of methyl-group metabolism and may contribute to abnormal DNA methylation, an early step in colonic carcinogenesis. A third contributing factor is that greater alcohol intake may increase the risk for colorectal cancer indirectly through immune suppression or delay of DNA repair. (Eunyoung et. all, 2004) The International Agency for Research on Cancer recently added colorectal cancer to the list of alcohol-related malignancies, and epidemiological studies have suggested that excessive alcohol intake increases the risk of this cancer. A United
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Kingdom dietary cohort study investigates this claim. The aim of this study was to examine the relationship between alcohol intake and overall colorectal cancer risks, including differences in sex-specific risks. It used a case–control study nested within the UK Dietary Cohort Consortium, from which nutritional data were ascertained by food diaries and food frequency questionnaires at baseline. (Park et. all, 2010) This study was conducted collaboratively by JY Park, CC Dahm, RH Keogh, PN Mitrou, BJ Cairns, DC Greenwood, EA Spencer, IS Fentiman, MJ Shipley, EJ Brunner, JE Cade, VJ Burley, GD Mishra, D Kuh, AM Stephen, IR White, RN Luben, AA Mulligan, K-T Khaw, and SA Rodwell, all of whom hold positions at the University of Cambridge in the United Kingdom. These researchers established 7 cohorts from the 153,000 participants carefully selected. Each cohort contained a group of people who had already been diagnosed with colorectal cancer, as well as a healthy control group. These separate groups were necessary to compare alcohol intake with the outcome of colorectal cancer. (Park et. all, 2010) Overall diet was assessed in addition to alcohol intake. Each cohort collected
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This note was uploaded on 11/16/2011 for the course MICROBIOLO 361 taught by Professor Ferguson during the Spring '11 term at Miami University.

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Epidemiologyresearchpaper - Hailey Holman MBI 361 Research...

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