104Lecture6

104Lecture6 - Lecture 6 4/19/11 Background reading: MBOC...

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Lecture 6 4/19/11 Background reading: MBOC 5 th Edition: Chapter 12: Pages 704 – 723, 736-737 4 th Edition: Chapter 12: pages 669 – 689, 698-703 Outline: Targeting and transfer of proteins to intracellular destinations. Protein transit to mitochondria and chloroplasts. Chaperones. Gated transport. Nuclear lamina. Co- and post-translational modifications of proteins in ER.
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Targeting and transfer of proteins to intracellular destinations Page 713 Molecular Biology of the Cell (© Garland Science 2008) Proteins destined for nucleus, mitochondria, peroxisomes, plastids and ER must transit across membrane. Proteins destined for all other organelles and for cell surface and cell exterior must first enter ER and then move on.
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Protein transit to mitochondria and chloroplasts Similarities to transit to ER: a) Utilize same basic mechanism as seen for the ER b) Signals usually cleaved after entry Differences from transit to ER: 1) Signals are different 2) Must cross two membranes to get into mitochondrial matrix or chloroplast stroma. Normally use one signal to get across both membranes and then a second signal to get to intramembrane space.
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This note was uploaded on 11/16/2011 for the course BIS 40175 taught by Professor Amenta during the Spring '11 term at UC Davis.

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104Lecture6 - Lecture 6 4/19/11 Background reading: MBOC...

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