Lecture 17b Packaging of Microfluidic and Optical

Lecture 17b Packaging of Microfluidic and Optical -...

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Packaging of Microfluidic and Optical Systems Dr. Bruce K. Gale Fundamentals of Micromachining Overview • Considerations in Biomedical Analysis Systems • Packaging in Biomedical Analysis Systems • Packaging of Microscale Bioreactors • Packaging of Micropipettes • Packaging of Microneedles • Packaging of Microchromatography Systems Considerations in Microscale Biomedical Analysis Systems • Biocompatibility – Defined for each application and system – Cells, proteins, DNA, tissues all have different requirements – Typically low protein absorption, no leaching, “non-reactive” • Harsh chemicals and environment • Small sample handling • Interfacing with macroscale world • Pumps, valves, flow control – High pressures, flow rates, and volumes possible • Sample injection • Multimodal: Fluids, Electrical, Optical, etc. • Interfaces with existing systems (standards) Modular Microsystems • The wide range of biomedical applications will require the use of modular microsystems • Multi-chip modules allow optimization of each component in a serial chain • Components include: separation, mixing, reaction, sample injection, sample preparation, various detection methods, pumping, flow control, control, intelligence, and other analysis • Parallel systems for high throughput • Standardization of platforms and connections
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Packaging of Analysis Systems • Biocompatibility encourages use of polymers • Requirements for biocompatible electrodes • Current interface method is a well – Clumsy, imprecise, and wasteful • Sample injection occurs at a “T” – Small sample tested – Most of the sample wasted
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Lecture 17b Packaging of Microfluidic and Optical -...

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