Lecture 26a BioMEMS

Lecture 26a BioMEMS - Biomedical Applications of MEMS...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
Biomedical Applications of MEMS Dr. Bruce K. Gale Fundamentals of Micromachining Biochip Technology with special thanks to Xiaolian Gao, University of Houston Genetic Database • Challenges – Function must be assigned to gene (discovery) – Location of gene determined (mapping) – How often is gene used (expression) – How do these genes differ between individuals (genetic variation) DNA Hybridization Arrays • High density arrays of polynucleotide probes • Used for genetic sequence analysis •Why do w e c
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
A C G T Probe (immobilized on a surface) Probe (immobilized on a surface) Target (in solution) Target (in solution) hybridization hybridization Basic Principles of DNA Basic Principles of DNA Microarrays Microarrays How Important is the Sequence ? How Important is the Sequence ? Biological relevance of SNPs (Single Nucleotide Polymorphism) 1 acatttgctt ctgacacaac tgtgttcact agcaacctca aacagacacc atggtgcacc 61 tgactcctg X ggagaagtct gccgttactg ccctgtgggg caaggtgaac gtggatgaag 121 ttggtggtga ggccctgggc aggctgctgg tggtctaccc ttggacccag aggttctttg 181 agtcctttgg ggatctgtcc actcctgatg ctgttatggg caaccctaag gtgaaggctc 241 atggcaagaa agtgctcggt gcctttagtg atggcctggc tcacctggac aacctcaagg 301 gcacctttgc cacactgagt gagctgcact gtgacaagct gcacgtggat cctgagaact 361 tcaggctcct gggcaacgtg ctggtctgtg tgctggccca tcactttggc aaagaattca 421 ccccaccagt gcaggctgcc tatcagaaag tggtggctgg tgtggctaat gccctggccc 481 acaagtatca ctagctcgct ttcttgctgt ccaatttcta ttaaaggttc ctttgttccc 541 taagtccaac tactaaactg ggggatatta tgaagggcct tgagcatctg gattctgcct 601 aataaaaaac atttattttc attgc Hemoglobin B Hemoglobin B Sequence Sequence If X = A, normal If X = T Sickle Cell Anemia • Fatigue, paleness, and shortness of breath Fatigue, paleness, and shortness of breath
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 11/16/2011 for the course MSE 5960 taught by Professor Douglas during the Fall '04 term at University of Florida.

Page1 / 5

Lecture 26a BioMEMS - Biomedical Applications of MEMS...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online