Lecture 2-2 - Lecture 2 - Genetics: Mutations 2/18/2011...

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Lecture 2 - Genetics: Mutations 2/18/2011 © Nicola Davies 2011 Genetics: Mutation and Sources of Genetic Variation Lecture 2 September 22, 2010 2 Mutants and Mutation Mutation drives biological variation which drives evolution Terminology: Mutant: organism with an altered base sequence in one or more genes. Usually has a phenotypic difference from wild type Wild Type: Unaltered “wild” organism Parental Strain: The parent from which a mutant strain came may be wild type or a mutant itself Creating/studying mutant strains is the basis for modern experimental biology 3 Defining and Counting Mutations Mutations traditionally defined by phenotype Now more common to define by genotype Two groups: point mutations and genomic rearrangements Point mutations: Silent to loss of function Rearrangements: Deletions, duplications, inversions or insertions Mutation rate typically calculated per doubling E. coli replisome: 1 error in 1x10 -6 bp copied
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This note was uploaded on 11/17/2011 for the course BIO 456 taught by Professor Smith during the Spring '11 term at Aberystwyth University.

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Lecture 2-2 - Lecture 2 - Genetics: Mutations 2/18/2011...

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