Lecture 2-4 - Lecture 4 - Genomics/Bacterial Genetics at...

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Lecture 4 - Genomics/Bacterial Genetics at Work 2/23/2011 © Nicola Davies 2011 Microbial Genetics at Work Lecture 4 September 29, 2010 2 Review: Making Mutations All methods fall into two categories: Random mutagenesis Site-directed mutagenesis Use random mutagenesis when: No genome sequence is available Studying a phenomenon/system for which genes are not identified Use site-directed mutagenesis when: A target is known Sequence data is available for the gene or region of interest To confirm results of random mutagenesis 3 Bacillus thuringiensis Close relative of B. anthracis Sporulateson plant surfaces Also makes a cradle for the spore: parasporal body Parasporal body contains crystallized proteins toxic to insects Activated in insect midgut Integrate into midgut cells forming pores Insect dies from starvation of bacterial infection Non-toxic to beneficial insects, animals, people Spread on crops for natural pest control
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This note was uploaded on 11/17/2011 for the course BIO 456 taught by Professor Smith during the Spring '11 term at Aberystwyth University.

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Lecture 2-4 - Lecture 4 - Genomics/Bacterial Genetics at...

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