Lecture4

Lecture4 - 01.20.10 Lecture 4 Cellular Building Blocks:...

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01.20.10 Lecture 4 Cellular Building Blocks: Lipids and Membranes
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Membranes form many compartments in the cell
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Biological membranes are composed of a lipid bilayer
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Membrane lipids are amphipathic molecules Membrane lipids are amphipathic Hydrophilic heads (polar) form hydrogen bonds with water Hydrophobic tails (non-polar) are excluded by water molecules
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Three classes of membrane lipids
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Membrane lipids Phosphatidylcholine is the most abundant phospholipid in cell membranes
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Packing arrangements of lipid molecules in an aqueous environment Cone-shaped lipid molecules for micelles, cylinder-shaped lipids form bilayers
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Phospholipid bilayers spontaneously close to form a sealed compartment
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The membrane bilayer is a fluid Lateral diffusion occurs rapidly within the plane of the membrane Individual phospholipids may rotate axially Flip-flopping from one side to the other is very rare as it is energetically unfavorable
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The membrane bilayer is a fluid: FRAP 1. A fluorescent probe is
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Lecture4 - 01.20.10 Lecture 4 Cellular Building Blocks:...

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