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Lecture6 - 01.25.10 Lecture 6 Intracellular compartments...

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01.25.10 Lecture 6 - Intracellular compartments and transport I
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Intracellular transport and compartments 1. Protein sorting: How proteins get to their appropriate destinations within the cell 2. Vesicular transport: How vesicles shuttle proteins and membranes between cellular compartments
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Primary functions of the compartments within a cell
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Relative cellular volumes of the major membranous organelles
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The evolution of organelles: nuclear membranes and ER
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The evolution of organelles: mitochondria
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Organelles import proteins by three distinct mechanisms 1. Transport from the cytoplasm into the nucleus through nuclear pores 2. Transport from the cytoplasm to organelles by protein translocators in the membrane 3. Transport from ER to other organelles occurs via vesicles
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Signal sequences target proteins to their destinations
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Signal sequences are necessary and sufficient for protein targeting
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Mechanism 1: proteins enter the nucleus via nuclear pores The nuclear envelope is a double membrane Contiguous with the ER - both compartments share the same lumen Perforated by nuclear pores
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