Lecture7

Lecture7 - 01.29.10 Lecture 7 - Intracellular compartments...

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Unformatted text preview: 01.29.10 Lecture 7 - Intracellular compartments and transport II SNAREs are proteins that target vesicles to specific compartments t-SNARES are on target compartments v-SNAREs are on vesicles SNARE proteins are important for membrane fusion v-SNAREs and t-SNAREs bind tightly Complexes bring the two membranes together to promote fusion Review of protein translocation 1. The secretory pathway: how newly made lipids, proteins, and carbohydrates are delivered to the cell surface via exocytosis 2. Endocytic pathways: how cells take up fluids and particles (large and small) from the extracellular environment Exocytosis & endocytosis Most (or all) proteins are covalently modified in the ER 1. Formation of disulfide bonds between cysteine residues of the same polypeptide (intra-molecular) or different polypeptides (inter-molecular) 2. Addition of short oligosaccharide side chains (glycosylation ) Formation of disulfide bonds occurs within the ER Oxidation of pairs of cysteine side chains Reaction cant occur in the cytoplasm Example: antibodies Many proteins are glycosylated in the ER 1. Polypeptide is translocated into ER lumen 2.2....
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This note was uploaded on 11/18/2011 for the course MATH 383H taught by Professor Euler during the Spring '08 term at UNC.

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Lecture7 - 01.29.10 Lecture 7 - Intracellular compartments...

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