Lecture7

Lecture7 - 01.29.10 Lecture 7 Intracellular compartments...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
01.29.10 Lecture 7 - Intracellular compartments and transport II
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
SNAREs are proteins that target vesicles to specific compartments t-SNARES are on target compartments v-SNAREs are on vesicles
Background image of page 2
SNARE proteins are important for membrane fusion v-SNAREs and t-SNAREs bind tightly Complexes bring the two membranes together to promote fusion
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Review of protein translocation
Background image of page 4
1. The secretory pathway: how newly made lipids, proteins, and carbohydrates are delivered to the cell surface via exocytosis 2. Endocytic pathways: how cells take up fluids and particles (large and small) from the extracellular environment Exocytosis & endocytosis
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Most (or all) proteins are covalently modified in the ER 1. Formation of disulfide bonds between cysteine residues of the same polypeptide (intra-molecular) or different polypeptides (inter-molecular) 2. Addition of short oligosaccharide side chains (glycosylation )
Background image of page 6
Formation of disulfide bonds occurs within the ER Oxidation of pairs of cysteine side chains Reaction can’t occur in the cytoplasm
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Example: antibodies
Background image of page 8
Many proteins are glycosylated in the ER 1. Polypeptide is translocated into ER lumen 2. Pre-formed, branched oligosaccharide (14 sugars)
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 11/18/2011 for the course MATH 383H taught by Professor Euler during the Spring '08 term at UNC.

Page1 / 26

Lecture7 - 01.29.10 Lecture 7 Intracellular compartments...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online