Lecture17

Lecture17 - 02.24.10 Lecture 17 - Cell motility Wednesday,...

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02.24.10 Lecture 17 - Cell motility Wednesday, February 24, 2010
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The Range of Cell Movement Velocities of moving cells span more than 4 orders of magnitude Each cell has evolved the speed and mechanism of its migration to match: Developmental programs The cell’s unique energy requirements The way the cell acquires nutrients The direction of cell migration is usually not random. .. Wednesday, February 24, 2010
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“-taxis” -Cell movement according to an environmental cue Can be an attracting or repelling signal Kinds of signals Chemotaxis - soluble factor (molecule or protein) Haptotaxis - same as chemotaxis, but the signal is immobilize on a surface Durotaxis - rigidity of the cell’s substrate Wednesday, February 24, 2010
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“-Taxis”, a form of cell signaling 1. Reception of signal 2. Transduction of signal 3. Cellular response Cell motility towards or away from the signal Wednesday, February 24, 2010
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Cellular locomotion is an essential part of life for many organisms Single celled protozoa - Dictyostelium discoideum http://www.youtube.com/watch?v=VWGA7kIeE0Q Wednesday, February 24, 2010
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Cellular locomotion is an essential part of life for many organisms Single celled protozoa - Dictyostelium discoideum http://www.youtube.com/watch?v=VWGA7kIeE0Q Mahadeo and Parent, 2006 Wednesday, February 24, 2010
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Embryonic development in animals Movements of autonomous cells or specialized cellular structures Cellular locomotion is an essential part of life for many organisms Early development - neurons migrating from their point of origin to their developmental destination Later Development - Once the neurons have found their home within the cerebral cortex they send out axons that stretch into other parts of the brain Chemoattractant Chemorepellent Wednesday, February 24, 2010
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Lecaudey, et al., 2008
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Lecture17 - 02.24.10 Lecture 17 - Cell motility Wednesday,...

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