Organic Lab Reactions 56 - THE USE OF INORGANIC FLUORIDES...

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THE USE OF INORGANIC FLUORIDES 51 METHODS OF PREPARATION Interaction of Organic Halides or Polyhalides with Inorganic Fluorides The replacement of a halogen atom in an organic compound by fluorine may be effected by treatment with any of several inorganic fluorides. The most important are mercury, silver, antimony, and hydrogen fluoride. The last is used whenever possible because of its low tcost, ease of handling, and high fluorine content. The fluorides of thallium, 1 zinc, 2 and potassium 3 - *• B have been used in isolated instances. The choice of the reagent is based on the reactivity of the halogen to be replaced. Iodine is most easily and chlorine least easily replaced; how- ever, side reactions are most prevalent-with iodides, which in conse- quence have not been used extensively. Bromides occupy an intermedi- ate plac,e both with respect to ease of replacement and extent of side reactions; they have been used most often in replacement reactions carried out in open equipment.
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