Lecture 11 WHI for pre-posting

Lecture 11 WHI for pre-posting - Interpreting the WHI Trial...

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Interpreting the WHI Trial
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Main Findings (from the abstract) Note: Hazard ratios can be interpreted as “instantaneous odds ratios” as observed throughout the duration of the study; they take into account the variable duration of follow-up in the treatment and control groups. In this study they can be interpreted as relative risks.
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Illustration of Some Key Concepts in the WHI Trial 1. Interpreting the main results (Table 2 + Figure 3) 2. Effectiveness of randomization (Table 1) 3. Equal observation in treatment and control groups (text p323) 4. Drop out rate (Fig 2 + text p326) 5. Testing for bias due to drop outs and crossovers (text p326) 6. Differential follow-up in treatment and control groups (p324 + Fig 3) 7. Unplanned cross-overs (Fig 2 + text p326) 8. Testing for bias due to unplanned crossovers (p329) 9. Analysis by Intention to Treat versus other methods (p329) 10. Additional (sub-group) analyses (text p328 and Table 4) 11. External Validity (generalizability) (p 331) 12. How to communicate the risks (p331 and next slides)
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Illustration of Some Key Concepts in the WHI Trial 1. Interpreting the main results (Table 2 + Figure 3) 2. Effectiveness of randomization (Table 1) 3. Equal observation in treatment and control groups (text p323) 4. Drop out rate (Fig 2 + text p326) 5. Testing for bias due to drop outs and crossovers (text p326) 6. Differential follow-up in treatment and control groups (p324 + Fig 3) 7. Unplanned cross-overs (Fig 2 + text p326) 8. Testing for bias due to unplanned crossovers (p329) 9. Analysis by Intention to Treat versus other methods (p329) 10. Additional (sub-group) analyses (text p328 and Table 4) 11. External Validity (generalizability) (p 331) 12. How to communicate the risks (p331 and next slides)
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What are hazard ratios? Hazard ratios can be interpreted as “instantaneous odds ratios” as observed throughout the duration of the study; they take into account the variable duration of follow-up in the treatment and control groups. In this study they can be interpreted as relative risks.
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What are nCIs and aCIs? Nominal confidence intervals (nCI) depict the precision with which the HR has been
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This note was uploaded on 11/20/2011 for the course NS 3500 taught by Professor Peletier during the Spring '11 term at Cornell.

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Lecture 11 WHI for pre-posting - Interpreting the WHI Trial...

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