Lecture 13 GSSI Omega 3 for pre-posting

Lecture 13 GSSI Omega 3 for pre-posting - Lecture 14 Omega...

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Unformatted text preview: Lecture 14: Omega 3 Fatty Acids The GSSI Prevenzione Trial of n3-PUFAs and Vit E Some Key Points: • Importance of the patient population • Importance of biological context of the disease • Importance of concomitant medical treatments • Importance of blinding • Importance of sensitivity and plausibility analysis Design of the GISSI Trial Patients <3 mos post-MI, 85% male, 50-80+ yrs, all taking post-MI meds for secondary prevention and changes in diet documented in 10-15% of subjects. What threats to validity do you see here? Threats? • Why is this table relevant when the study is an RCT? • What patterns do you see in the data? • Why is that important to the study? Three sets of measurements related to implementation of the trial. Any comments or concerns? Outcomes Samples Sizes for theTwo-way and Four-Way Analyses in the GISSI Trial (sample sizes in paper are inconsistent) N-3 PUFA No N-3 PUFA Totals Vit E a n=2830 b n= 2830 N=5660 No Vit E c n=2836 d n= 2828 N=5664 Totals N=5666 N=5668 N=11,324 Four-Way: Effect of n-3 PUFA: c vs d Effect of Vit E: b vs d Two-Way: Effect of n-3 PUFA:...
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This note was uploaded on 11/20/2011 for the course NS 3500 taught by Professor Peletier during the Spring '11 term at Cornell.

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Lecture 13 GSSI Omega 3 for pre-posting - Lecture 14 Omega...

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