ANAT 1502 Fertilization and Implantation

ANAT 1502 Fertilization and Implantation - Zona pellucida...

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1st Week of Development • Fertilization • Cleavage • Blastocyst formation Monday, July 12, 2010
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Fertilization • Site: ampulla of uterine tube • Capacitation of sperm • Phases – passage through the corona radiata – passage through zona pellucida (impermeable) – fusion of plasma membranes – completion of 2nd meiotic division of oocyte – formation of male/female pronuclei – mitosis Monday, July 12, 2010
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Results of Fertilization • Zygote • Restores normal diploid number of chromosomes • Variation of species • Gender determination • Initiation of cleavage Monday, July 12, 2010
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Stages of Human Development • Zygote - spermatozoon and ovum unite • Morula - 12 -32 blastomeres • Blastocyst - has a fluid filled cavity • Embryo - 3rd to 8th week • Fetus - from embryo to birth Monday, July 12, 2010
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Cleavage of Zygote • Begins about 30 hours after fertilization • Forms blastomeres • Blastomeres become compacted • Segregation • Morula (3 days) Monday, July 12, 2010
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Formation of Blastocyst • Fluid enters morula (blastocyst cavity)
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Unformatted text preview: Zona pellucida is shedded implantation differentiation Trophoblast cytotrophoblast syncytiotrophoblast (cell fusion) Inner cell mass epiblast hypoblast Monday, July 12, 2010 Extraembryonic Structures Amniotic cavity Amnion Yolk sac Connecting stalk Chorionic sac Monday, July 12, 2010 Implantation Begins at the end of the 1st week, ends at the end of 2nd week Blastocyst implants at embryonic pole Decidual cells (from endometrium) nourish embryo Monday, July 12, 2010 Implantation Sites Body of the uterus (most typical) Monday, July 12, 2010 Summary of Implantation Begins the end of week 1 zona pellucida degenerates blastocyst adheres to endometrium syncytiotrophobast and cytotrophoblast form lacuna appear, lacunar networks form, and the primitive uteroplacental circulation is established primary chorionic villi develop Monday, July 12, 2010...
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ANAT 1502 Fertilization and Implantation - Zona pellucida...

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