CHEM 1516 Exam 4 Review #2 - -need HMG CoA to make 2 AcCoA...

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BioChem II Final Exam Notes -Fatty Acid Synthesis -occurs in cytoplasm -AcCoA is shuttled from the matrix to the cytoplasm via citrate -to build a fatty acid: AcCoA AcCoA Carboxylase AcCoA + Malonyl CoA CO 2 C – C – C – COOH + AcCoA = C – C – C – C – C – COOH Fatty Acid Synthase Fatty Acid Synthase * * * -Fatty Acid Catabolism -even #/saturated easier to break down -odd #/unsaturated harder to break down -occurs in matrix -produces AcCoA to feed the TCA cycle NADH FADH 2 NADH FADH 2 NADH FADH 2 C – C - C – C - C – C - C – C OOH AcCoA AcCoA AcCoA AcCoA * * * Cholesterol -made up of: HMG CoA + Isoprene + Squalene * * * Creatine Creatine Phosphate Creatinine creatine kinase (kidney disease) (can confirm myocardial infarction) * * *
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Dead RBC’s Spleen (in small intestine) Heme (porphyrin) bilirubin uribilin reabsorbed Liver (makes bile) stercobilin shit out * * * -Ketone Bodies
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Unformatted text preview: -need HMG CoA to make 2 AcCoA Acetone Acetoacetate -Hydroxybutyrate * * *-Nitrogen Metabolism Amino Acid Carbon Skeleton NH 2 glutamate -KG aspartate OAA H C COOH alanine pyruvate R Transamination-enzyme = transaminase / aminotransferase NH 2 NH 2 OAA -KG OAA -KG (aspartate) (glutamate) Oxidation Deamination matrix cytoplasm ( glutamate DH) (carbonyl phosphate synthase) NH 2 NH 2 Carbonyl Urea Phosphate a-KG CO 2 ATP Urea Cycle * see large diagram * * *-Ketogenic Amino Acids-Luecine/Lycine # of Rings Precursors End Product Salvaged for ? Purines 2 THF Uric Acid ATP A G Inosine GTP Pyrimidines 1 Orotic Acid Urea New DNA C T U New RNA * * *-HMP Shunt (hexomonophosphate) Glucose NADPH (anti-oxidant) oxidative G6P Ribose F6P non-oxidative...
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CHEM 1516 Exam 4 Review #2 - -need HMG CoA to make 2 AcCoA...

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