2011ImmunologyRev - TheChallenge mortality(Vaccines...

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8/25/2011 1 The Challenge Infectious Diseases with high morbidity and mortality: (Vaccines?) Annual incidence Mortality Malaria 300 500M ~2M Schistosomiasis ? 8000 Diarrhea ~4billion ~4M Tuberculosis ~9M ~2M Respiratory ~362M ~4M HIV ~40M ~3M
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8/25/2011 2 The Immune Response: I. Innate immunity The Innate Immune response is defined as that which the body mounts without previous contact with a microbe. It is not specific to microbe. Components of innate immunity: outer surface of body (skin) Linings of internal tracts secretions Phagocytic cells (macrophages, neutrophils) and natural killer cells. Soluble blood proteins: Complement Effectors of innate immunity Induction of inflammation at site of infection, release of chemical mediators – Interferons, complement components … Phagocytosis Complement mediated lysis
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8/25/2011 3 Cells of the Immune System Overview
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8/25/2011 4 Definitions Antigen molecules that react with antibodies or T cells Antibody : plasma proteins produced by B cells that bind specifically to antigens Immunogen : those antigens that can induce specific immune response such as antibody production. Antigenic determinant : portion of antigen that is bound by a given antibody or recognized by T cell epitope .
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