Excystation discussion

Excystation discussion - • Tracking of cyst wall...

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Excystation/Encystation in parasitic protozoa Paper by Daniel Eichinger
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Giardia sp. -L i feCyc le
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Excystation • What are the prevailing conditions in the stomach, which the Giardia cyst might encounter? • Where does excystation occur • What are some characteristics of the Giardia trophozoites that emerge after excystation? • What is known about Entamoeba excystation?
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Giardia encystation • In which region of intestine does this occur? • Does parasite density contribute to encystation? • How does lipid availability affect the process? • What is the ‘downstream flow model’? Entamoeba • Where do they reside? • What factors contribute to the site preference of Entamoeba ? • Which parasite molecule(s) is implicated in the encystation response? What is the suggested role? • What have studies on signaling revealed?
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Secretion and role of golgi
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Giardia – changes in cell composition • What are encystation-specific secretory vesicles (ESVs)? What have studies on these structures revealed?
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Unformatted text preview: • Tracking of cyst wall proteins (cwp) following GFP tagging Composition of Cyst • What is composition of Giardia cyst? • Filamentous wall 43% carb – 86% of which is N-acetyl galactose amine (galNAc). • Which are the unique components in the galNAc synthesis pathway? • What is the source of ammonia? What role does this play in pathogenesis? Unique donor and enzyme Unique enzyme NO Giardia – changes in cell composition • What are encystation-specific secretory vesicles (ESVs)? What have studies on these structures revealed? • They describe unique enzymes involved in synthesis of cell wall sugars (GPI), and also the requirement for NH 3 (arginine). What role do these molecules play in pathogenesis? Composition of cyst wall of Entamoeba • What is the composition of the cyst wall? How does it differ from that of Giardia? • What is Jacob? • What is the status of the golgi in these organisms? • Final thoughts?...
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Excystation discussion - • Tracking of cyst wall...

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