Excystation discussion

Excystation discussion - Tracking of cyst wall proteins...

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Excystation/Encystation in parasitic protozoa Paper by Daniel Eichinger
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Giardia sp. -L i feCyc le
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Excystation • What are the prevailing conditions in the stomach, which the Giardia cyst might encounter? • Where does excystation occur • What are some characteristics of the Giardia trophozoites that emerge after excystation? • What is known about Entamoeba excystation?
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Giardia encystation • In which region of intestine does this occur? • Does parasite density contribute to encystation? • How does lipid availability affect the process? • What is the ‘downstream flow model’? Entamoeba • Where do they reside? • What factors contribute to the site preference of Entamoeba ? • Which parasite molecule(s) is implicated in the encystation response? What is the suggested role? • What have studies on signaling revealed?
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Secretion and role of golgi
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Giardia – changes in cell composition • What are encystation-specific secretory vesicles (ESVs)? What have studies on these structures revealed?
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Unformatted text preview: Tracking of cyst wall proteins (cwp) following GFP tagging Composition of Cyst What is composition of Giardia cyst? Filamentous wall 43% carb 86% of which is N-acetyl galactose amine (galNAc). Which are the unique components in the galNAc synthesis pathway? What is the source of ammonia? What role does this play in pathogenesis? Unique donor and enzyme Unique enzyme NO Giardia changes in cell composition What are encystation-specific secretory vesicles (ESVs)? What have studies on these structures revealed? They describe unique enzymes involved in synthesis of cell wall sugars (GPI), and also the requirement for NH 3 (arginine). What role do these molecules play in pathogenesis? Composition of cyst wall of Entamoeba What is the composition of the cyst wall? How does it differ from that of Giardia? What is Jacob? What is the status of the golgi in these organisms? Final thoughts?...
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Excystation discussion - Tracking of cyst wall proteins...

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