CancerProjectOverview

CancerProjectOverview - Project 3 Project s Does...

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Project 3 Project 3 Does continuation of antiangiogenic therapy throughout the entire course of treatment for advanced colon cancer improve patient outcome?
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Colorectal Cancer in the U.S: Colorectal Cancer in the U.S: The Facts The Facts 3rd most common, second deadliest 135,400 new cases, 56,700 deaths 1.26 million living with CRC; 6% lifetime risk We will focus on metastatic colon cancer (stage IV), < 5% 5 year survival
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Metastatic Colon cancer Metastatic Colon cancer Treatment Treatment Initial treatment: FOLFOX + Bevacizumab CPT-11 + Cetuximab after ‘failure’ No regimens completely standardized, many types of ‘failure’ Glossary: FOLFOX = 5-FU + Leucovorin + Oxaliplatin IFL = 5-FU + Leucovorin + irinotecan CPT-11 = Irinotecan
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First Line: IFL vs IFL + BEV
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Overall Survival 0 10 20 30 40 50 60 70 80 90 100 0 1 2 Years % Alive IFL FOLFOX P-value=0.0009 First Line: IFL vs FOLFOX
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2nd Line: FOLFOX vs FOLFOX + BEV
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Figure 4 displays the Kaplan-Meier curve for survival beyond 1
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This note was uploaded on 11/21/2011 for the course PUBH 7420 taught by Professor Ph7420 during the Spring '07 term at Minnesota.

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CancerProjectOverview - Project 3 Project s Does...

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