CVDProjectOverview

CVDProjectOverview - Project 1 Project 1 Is a...

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Unformatted text preview: Project 1 Project 1 Is a chlorthalidone (C) based blood pressure (BP) lowering regimen superior to a hydrochlorothiazide (H) based regimen in lowering night-time BP and in preventing cardiovascular disease (CVD) morbidity and mortality? If so, can differences be attributed to better BP control or pleiotropic effects of C. H vs C Study Rationale H vs C Study Rationale Nearly 50% of the 70 million people in the U.S. with hypertension are not controlled. A thiazide diuretic is an important component of antihypertensive regimens. Current treatment recommendations do not differentiate among diuretics. There is substantial evidence that low doses of C (25 mg daily) are effective reducing CVD morbidity and mortality. There is less outcome data on low doses of H (12.5 or 25 mg daily). H is used far more than C. There are no large trials comparing H and C for CVD morbidity and mortality. Major Diuretic Trials Major Diuretic Trials VA Coop (1967) HCTZ 50-100 mg PHS trial (1977) Chlorothiazide 500-1000 mg HDFP (1982) Chlorthalidone 25-100 mg MRFIT (1990) HCTZ 50-100 mg (BID) or Chlorthalidone 50-100 mg EWPHE (1985) HCTZ 25-50 mg MRC (1992) HCTZ 25-50 mg SHEP (1991) Chlorthalidone 12.5-25 mg TOMHS (1993) Chlorthalidone 15-30 mg ALLHAT (2002) Chlorthalidone 12.5-25 mg ACCOMPLISH (2008) HCTZ 12.5-25 mg Diuretics and CVD Events Diuretics and CVD Events 5 trials have demonstrated the benefit of chlorthalidone-based regimen in reducing CVD events. No comparator has proven superior....
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This note was uploaded on 11/21/2011 for the course PUBH 7420 taught by Professor Ph7420 during the Spring '07 term at Minnesota.

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CVDProjectOverview - Project 1 Project 1 Is a...

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