HIVProjectOverview

HIVProjectOverview - Project 2 Project s Among HIV-infected...

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Project 2 Project 2 Among HIV-infected participants in sub-Saharan Africa, does initiation of antiretroviral treatment (ART) at CD4+ counts above 500 cells/mm 3 result in a reduction in all-cause mortality compared to deferral of initiation of ART until the CD4+ declines to < 350 cells/mm 3 ?
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Reasons for Deferral Reasons for Deferral In high-income countries, absolute risk differences for AIDS or death are small compared with those at lower CD4+ counts (no good data for sub-Saharan Africa) Concerns about complications of ART Fear of waning adherence, resistance accumulation, and exhaustion of drug options Unknown HIV status
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3 Year Risk of AIDS or Death 3 Year Risk of AIDS or Death Following the Initiation of ART* Following the Initiation of ART* 0 3 6 9 12 15 % 100-199 200-349 200-349 350+ * VL < 5 log 10 copies/mL, CDC stage A/B, and no history of IDU ART Collaboration, Lancet 2002 CD4+ Cell Count at ART Initiation Risk Difference 49% Relative 4.6% Absolute Risk Difference 29% Relative 1.3% Absolute
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HIVProjectOverview - Project 2 Project s Among HIV-infected...

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