Lectures_02 - 3— DOM gfififi‘c MM 13 m 600 NAM/x wow...

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Mme/ewx B ”/4 {”0ng Jr Loggia) ,1. %w) + 0734c) E ( @MpM U5 “‘5 9‘1?” WM UMQDM hum/{Ti ufiwfikfzsz‘fl UM M‘CMLM) ~wa5f‘2rm SMUM‘ 3/3931 wank 0w? m {Mali WW, I /’r 2);; 42,3108 2291: m 9929 £7th @614 may. Mite/£575 TABLE 11 Protein Composition of the 929 Prohead and Virion __________________________——— ____________________________——— Gene product (structure) 9P7 (scaffold) 998 (major capsid) gp10 (connector) gp8.5 (head fiber) gp11 (lower collar) 9912* ’ (appendage) 9109 (tail) 1/13/008 Statistical Copiesa method REML 25.8 Bayesian 26.9 REML 231.9 Bayesian 232.4 12 REML 53.5 Bayesian 52.6 REML 11.2 Bayesian 11.2 REML 58.6 Bayesian 58.2 REML 9. Bayesian 9 Standard error 3.4 8.8 15.7 17.7 7.9 14.7 93.0 030-1 9°93 44> 91.0 010) 95% Confidence interval (19.0, 32.6)d (13.6, 40.9)8 (200.5, 263.3) (199.8, 266.5) (37.7. 69.3) (29.1, 74.4) (10.3, 12.1) (5.6, 16.6) (51.9, 65.3) (44.7, 71.2) (7.9, 10.3) (3.3, 15.2) 991“} 600% AMI—6M 32m @79ka WUW‘My Haw Slumfl m6 {dram Wet/1A? .‘ QEML mwngKJ T74 fCJYLflc/{Ta/ {:‘(La/[Lwnfl lA’AMm l/bL/(O An example where the REML estimate = 0 (loanna Panoutsopoulou, Kennedy Lab) Comparing blisters vs. skin biopsy for estimating epidermal nerve density RE: 19 subjects FE: 2 locations/subject (thigh, calf) RE: subject x location RE: 2 blisters/location/subject Some missing data, of course; n = 136 total Dependent variable: Axons/mm2 in epidermis REML Variance Component Estimates Variance Random Effect Estimate 95% Cl Subj ID 18031 8473 61169 Subj lD*Loc 9561 4684 29197 BIister[Subj |D,Loc] O O 0 Residual 6696 5181 8992 Fix the other 3 VCs at their REML estimates The log RL declines by 2 log units when the blister VC is about 1550 — not small compared to residual variance IA2/24b 1/22/10 Nznp Redraw (MM .1~ (M (MMM # jawewmmm) RL (45;:le (9‘; Eff SE/Méf) Wm: (552+ gel/A) (a; ,ch (, 5M flaws/n3) WK S’E : 21:9 «My g”: W111 “31“)“ (012mm; :~ K “0153607 (0%)» 3; 26: “Q; “7 (Q‘s/0 “ gM/Mm; A) F" 10001)) E[§M/[Pq)) : 651+ (fez h I f0 1M; I; [la mamafzffi‘na/bv Paw F! 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