PUBH 1517 - Lipids 2 - Eicosanoids Paracrine Mediators...

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Eicosanoids & Paracrine Mediators Injury or inflammation causes cleavage of PUFAs (Arachadonic or EPA) from phospholipid bilayer of cell membrane These fatty acids enter pathways for eicosanoid (eicosa = 20) synthesis in the production of paracrine hormones
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Differences Between Omega- 3 & Omega-6 Eichosanoid Effects Weaker effect with Omega-3 Platelets less likely to aggregate With Omega-3, fibrinogen & other clotting proteins reduced, platelet survival increased, decreased thrombus risk Omega 3s result in more endothelial cell-derived relaxation factor
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Eicosanoids Omega-6 : Thromboxane A2 (vasoconstictor) platelet aggregation Prostaglandin 2 (vasodilator), platelet antiaggregation Leucotriene 4 Omega-3 : Thromboxane A3 (vasoconstrictor) Prostaglandin 3 (vasodilator) Leukotriene 5
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Omega-3 vs Omega-6 Inflammatory Process EPA, DHA, and ALA (Omega-3s) have all been shown to reduce synthesis of aggressive inflammatory response cytokines by interfering with the conversion of arachidonic acid in various pathways Study has shown improvement in rheumatic arthritis symptoms with supplemental doses (2.6g) of Omega-3 fatty acids.
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Anti-inflammatory Drug Effects Cortisone inhibits cleavage of the PUFA from the membrane Aspirin inhibits prostaglandin synthesis
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This note was uploaded on 11/21/2011 for the course PUBH 1517 taught by Professor Paula.goldberg during the Winter '11 term at Life Chiropractic College West.

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PUBH 1517 - Lipids 2 - Eicosanoids Paracrine Mediators...

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