MICR 1531 Neonatal Circumcision Effects

MICR 1531 Neonatal Circumcision Effects - THE LANCET Effect...

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THE LANCET Summary Background Preliminary studies suggested that pain experienced by infants in the neonatal period may have long-lasting effects on future infant behaviour. The objectives of this study were to find out whether neonatal circumcision altered pain response at 4-month or 6-month vaccination compared with the response in uncircumcised infants, and whether pretreatment of circumcision pain with lidocaine-prilocaine cream (Emla) affects the subsequent vaccination response. Methods We used a prospective cohort design to study 87 infants. The infants formed three groups—uncircumcised infants, and infants who had been randomly assigned Emla or placebo in a previous clinical trial to assess the efficacy of Emla cream as pretreatment for pain in neonatal circumcision. Infants were videotaped during vaccination done at the primary care physician’s clinic. Videotapes were scored without knowledge of circumcision or treatment status by a research assistant who had been trained to measure infant facial action, cry duration, and visual analogue scale pain scores. Findings Birth characteristics and infant characteristics at the time of vaccination, including age and temperament scores, did not differ significantly among groups. Multivariate ANOVA revealed a significant group effect (p<0·001) in difference (vaccination minus baseline) values for percentage facial action, percentage cry time, and visual analogue scale pain scores. Univariate ANOVAs were significant for all outcome measures (p<0·05): infants circumcised with placebo had higher difference scores than uncircumcised infants for percentage facial action (136·9 vs 77·5%), percentage cry duration (53·8 24·7%), and visual analogue scale pain scores (5·1 3·1 cm). There was a significant linear trend on all outcome measures, showing increasing pain scores from uncircumcised infants, to those circumcised with Emla, to those circumcised with placebo. Interpretation Circumcised infants showed a stronger pain response to subsequent routine vaccination than uncircumcised infants. Among the circumcised group, preoperative treatment with Emla attenuated the pain response to vaccination. We recommend treatment to prevent neonatal circumcision pain. Lancet 1997; 349: 599–603 Introduction Neonatal circumcision is a common surgical procedure in male infants. Despite evidence that circumcision causes intense pain and short-term alterations in infant feeding, sleeping, and crying behaviours, 1–3 analgesia is rarely given. 4–6 There is a common belief that the effects of circumcision pain are short-lived and clinically insignificant, and, therefore, that the benefits of analgesic treatment do not outweigh the risks of adverse effects from currently available therapies. 7,8
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This note was uploaded on 11/21/2011 for the course MICR 1531 taught by Professor Shahlaabghari during the Winter '11 term at Life Chiropractic College West.

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MICR 1531 Neonatal Circumcision Effects - THE LANCET Effect...

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