PHYS 1525 Bilirubin StepByStep

PHYS 1525 Bilirubin StepByStep - Briey, when the red blood...

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Briefy, when the red blood cells have lived out their liFe span (on average, 120 days) and have become too Fragile to exist in the circulatory system, their cell membranes rupture, and the released hemoglobin is phagocytized by tissue macrophages (also called the reticuloendothelial system) throughout the body. o The hemoglobin is ±rst split into globin and heme . o The heme ring is opened to give Free iron. o Then it is transported in the blood by transFerring a straight chain oF Four pyrrole nuclei. Which is the substrate From which bilirubin will eventually be Formed. o The ±rst substance Formed is biliverdin . o Bliverdin is rapidly reduced to free bilirubi . o Free bilirubi is gradually released From the macrophages into the plasma. o The Free bilirubin immediately combines strongly with plasma albumin. o It is then transported in this combination throughout the blood and interstitial fuids. Even when bound with plasma protein, this bilirubin is still
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This note was uploaded on 11/22/2011 for the course PHYS 1525 taught by Professor Lescane during the Winter '11 term at Life Chiropractic College West.

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PHYS 1525 Bilirubin StepByStep - Briey, when the red blood...

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