mtDNA from a third Neandertal

mtDNA from a third Neandertal - mtDNA from a third...

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mtDNA from a third Neandertal In 2000, scientists announced the sequencing of a third Neandertal mtDNA specimen from a cave at Vindija, Croatia (Krings et al. 2000). When the three Neandertals are compared with modern humans, all three of them cluster together, and apart from all modern humans. This conclusion is reinforced by a study by Knight (2003). Knight excluded from the comparison sites in the mtDNA genome which are known to have mutated more than once, and which are therefore poor indicators of phylogenetic relationships. His study strongly confirmed earlier ones showing deeply divergent histories for modern human mtDNA lineages and the known Neandertal ones. Like modern humans, Neandertals had low genetic diversity compared to apes. The diversity of the three Neandertal mtDNA sequences (3.73%) is lower than that of chimpanzees (14.82+/- 5.7%) and gorillas (18.57+/-5.26%), and similar to that of modern humans worldwide (3.43+/- 1.22%). If modern humans are sorted into continental groups, the diversity of the three Neandertals is similar to (within one standard deviation of) that for Africans, Asians, native Americans and Australian aboriginals, and Oceanians. Modern Europeans, who live in approximately the same region as the Neandertals, have less diversity than the Neandertals.
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This note was uploaded on 11/22/2011 for the course GLY GLY1100 taught by Professor Jaymuza during the Spring '10 term at Broward College.

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mtDNA from a third Neandertal - mtDNA from a third...

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