This preview shows pages 1–2. Sign up to view the full content.
This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: undifferentiated embryonic connective tissue Response to external micro-environment signals and internal lineage signals - not well understood. ? Growth Factors ? Cytokines By 6 th week the undifferentiated model starts to differentiate down one of two routes depending upon the site of development Intramembranous Osteogenesis This method of bone development involves the laying down of bone tissue directly in the primitive connective tissue or mesenchyme. No cartilage pre-cursor. This type of development is seen in the flat bones of the skull, parts of the temporal, mandible and maxilla 1. Mesenchyme condenses and is highly vascular 2. Mesenchyme cells differentiate into Osteoblasts 3. Matrix secretion osteoid 4. Bone osteoblasts trapped mature into osteocytes Bone organised into layers Lamellae Bone grown in a haphazard manor Callus/Woven Bone...
View Full Document