Cholinergic Receptors

Cholinergic Receptors - CholinergicReceptors

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Cholinergic Receptors  The two types of receptors that bind ACh are named for drugs that bind to them and mimic ACh  effects.  1. Nicotinic  2. Muscarinic (mushroom poison)  Muscarine has no effect on nicotinic receptors, and vice versa.  Nicotinic  receptors are found on:  1. motor end plates of skeletal muscle cells 2. postganglionic neurons 3. hormone-producing cells of the adrenal medulla  The effect of ACh binding to nicotinic receptors is always  stimulatory Muscarinic  receptors occur on all effector cells stimulated by postganglionic cholinergic fibers -  all parasympathetic target organs and a few sympathetic targets. The effect of ACh binding to  muscarinic receptors is  inhibitory or stimulatory , depending on the target organ. Binding of ACh  to cardiac muscle receptors slows heart activity, whereas ACh binding to receptors on smooth  muscle of the G.I. tract cause increased motility. 
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Cholinergic Receptors - CholinergicReceptors

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